Eugene Chang, MD

Associate Professor, Otolaryngology
Vice Chair, Academic Affairs - Otolaryngology
Associate Professor, BIO5 Institute

Research Interest: 

Dr. Chang’s research is divided into three areas. Cystic fibrosis (CF) research: Dr. Chang is investigating the role of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in the pathogenesis of chronic sinusitis. He published the first animal model of CF sinus disease, and has characterized novel therapies including gene therapy vectors and CFTR potentiators in improving CF sinus disease in both animals and humans. Sinus microbiome research: the “microbiome” is the microbial community that is present in the human body. The sinonasal cavities have traditionally been thought to be sterile cavities, but new research is beginning to elucidate the vast number of microbial communities that populate our sinus. With this knowledge, we are investigating how our current therapies can influence this microbial population and prevent sinus disease. Impact of the upper and lower airway: as otolaryngologists, our focus has been in the airway of the head and neck. Dr. Chang has been investigating how the upper airway can influence disease of the lower airway, and vice versa. This research can influence the understanding of common diseases of the lower airway, such as asthma and chronic obstructive pulmonary disease (COPD). Dr. Chang receives active funding research support from the NIH, and the Cystic Fibrosis Foundation

Selected Publications


Chang EH, Willis AL, Romanoski CE, et al. "Rhinovirus Infections in Individuals with Asthma Increase ACE2 Expression and Cytokine Pathways Implicated in COVID-19." Am J Respir Crit Care Med. 2020;202(5):753-755. PMCID: PMC7462393  PMID: 32649217


Chang EH, Willis AL, McCrary HC, et al. "Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis." J. Allergy Clin. Immunol.. 2017;139(6):1990-1992.e2. PMCID: PMC5457723  PMID: 27923563