Sleep intervention during Acute Lung Injury (R01 NIH/NHLBiHL095748): The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis on sleep and inflammation in critically ill patients with acute lung injury(ALI) and acute respiratory distress syndrome (ARDS). Clinicaltrials.gov# NCT01050699 Positive airway pressure therapy for sleep-disordered breathing (ADVENT-HF; Canadian Institute of Health Research [CIHR] and Toronto Rehabilitation Institute, Toronto, Canada): The central purpose of this proposal is to assess the effect of adaptive servo ventilation (ASV) on mortality and cardiovascular hospitalizations in patients with chronic heart failure and sleep apnea. Clinicaltrials.gov#NCT01128816 Adherence to CPAP Therapy in patients with sleep-disordered breathing (US Dept. of Veterans Affairs; PPO 10-066): Our overall aim is to assess the feasibility and acceptability of a CPAP adherence program driven by trained "peer-buddies" with sleep apnea. Clinicaltrials.gov# NCT01164683 Sleep deprivation in murine models (Johrei foundation): The central purpose of this proposal is to study the sleep-promoting effects of Johrei treatment in a murine sleep deprivation model.