Sairam Parthasarathy, MD

Professor, Medicine
Interim Chief, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine
Director, Center for Sleep and Circadian Sciences, UA Health Sciences
Medical Director, Center for Sleep Disorders, Banner – University Medical Center Tucson

Research Interest: 

Sleep intervention during Acute Lung Injury (R01 NIH/NHLBiHL095748):  The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis on sleep and inflammation in critically ill patients with acute lung injury(ALI) and acute respiratory distress syndrome (ARDS). NCT01050699 Positive airway pressure therapy for sleep-disordered breathing (ADVENT-HF; Canadian Institute of Health Research [CIHR] and Toronto Rehabilitation Institute, Toronto, Canada):  The central purpose of this proposal is to assess the effect of adaptive servo ventilation (ASV) on mortality and cardiovascular hospitalizations in patients with chronic heart failure and sleep apnea. Adherence to CPAP Therapy in patients with sleep-disordered breathing (US Dept. of Veterans Affairs; PPO 10-066):  Our overall aim is to assess the feasibility and acceptability of a CPAP adherence program driven by trained "peer-buddies" with sleep apnea. NCT01164683 Sleep deprivation in murine models (Johrei foundation):  The central purpose of this proposal is to study the sleep-promoting effects of Johrei treatment in a murine sleep deprivation model.

Selected Publications


Knobbe K, Partha M, Seckeler MD, et al. "Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health-Related Quality of Life in Children With Fontan Circulation." J Am Heart Assoc. 2021;10(21):e021749. PMCID: PMC8751823  PMID: 34668394


Combs D, Edgin JO, Klewer S, et al. "OSA and Neurocognitive Impairment in Children With Congenital Heart Disease." Chest. 2020;158(3):1208-1217. PMCID: PMC7478226  PMID: 32222588

Mashaqi S, Mansour HM, Alameddin H, et al. "Matrix metalloproteinase-9 as a messenger in the crosstalk between obstructive sleep apnea and comorbid systemic hypertension, cardiac remodeling, and ischemic stroke: a literature review." J Clin Sleep Med. 2020.

Clinical Trials

Study Title (link to more info on this site)sort descending Link to Study Trial Status Principal Investigator
Peer-Driven Intervention for Sleep Apnea (PCORI) Current Trial - Enrollment Complete Sairam Parthasarathy, MD
Sleep Intervention During Acute Lung Injury Current Trial - Enrollment Complete Tara F. Carr, MD, Sairam Parthasarathy, MD