Stefano Guerra , MD, PhD, MPH

Professor, Medicine
The Henry E. Dahlberg Chair in Asthma Research
Director, Population Sciences, A2DRC
Professor, UA Mel & Enid Zuckerman College of Public Health
Professor, UA BIO5 Institute
Research Scientist, A2DRC

Selected Publications


Voraphani N, Stern DA, Zhai J, et al. "The role of growth and nutrition in the early origins of spirometric restriction in adult life: a longitudinal, multicohort, population-based study." Lancet Respir Med. 2022;10(1):59-71. PMID: 34843665


Johnson MDL, Younis US, Menghani SV, et al. "CC16 Binding to αβ Integrin Protects against Infection." Am J Respir Crit Care Med. 2021;203(11):1410-1418. PMCID: PMC8456541  PMID: 33326355

Wang G, Kull I, Bergström A, et al. "Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort." Thorax. 2021;76(5):503-507. PMCID: PMC8070638  PMID: 33184098


Polverino F, Stern DA, Ruocco G, et al. "Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)." Front Cardiovasc Med. 2020;7:585866. PMCID: PMC7583635 

Zhou JJ, Zhai J, Zhou H, et al. "Supraglottic Lung Microbiome Taxa Are Associated with Pulmonary Abnormalities in an HIV Longitudinal Cohort." Am J Respir Crit Care Med. 2020;202(12):1727-1731. PMCID: PMC7737582  PMID: 32783620

Guerra S, Lombardi E, Stern DA, et al. "Fetal Origins of Asthma: A Longitudinal Study from Birth to Age 36 Years." Am. J. Respir. Crit. Care Med.. 2020. PMID: 32649838


Zhai J, Insel M, Addison KJ, et al. "Club Cell Secretory Protein Deficiency Leads to Altered Lung Function." Am. J. Respir. Crit. Care Med.. 2019;199(3):302-312. PMCID: PMC6363971  PMID: 30543455

Beamer PI, Furlong M, Lothrop N, et al. "CC16 Levels into Adult Life are Associated with Nitrogen Dioxide Exposure at Birth." Am. J. Respir. Crit. Care Med.. 2019. PMID: 30789752


Guerra S, Melén E, Sunyer J, et al. "Genetic and epigenetic regulation of YKL-40 in childhood." J. Allergy Clin. Immunol.. 2018;141(3):1105-1114.

Chang EH, Stern DA, Willis AL, Guerra S, Wright AL, Martinez FD. "Early life risk factors for chronic sinusitis: A longitudinal birth cohort study." J. Allergy Clin. Immunol.. 2018;141(4):1291-1297.e2. PMCID: PMC5937937  PMID: 29355680

Martinez FD, Guerra S. "Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction." Am. J. Respir. Crit. Care Med.. 2018;197(5):573-579. PMCID: PMC6005239  PMID: 29048927

Gerhart KD, Stern DA, Guerra S, Morgan WJ, Martinez FD, Wright AL. "Protective effect of breastfeeding on recurrent cough in adulthood." Thorax. 2018;73(9):833-839.

Huang S, Hu C, Bell ML, et al. "Regularized continuous-time Markov Model via elastic net." Biometrics. 2018;74(3):1045-1054.

Vasquez MM, Zhou M, Hu C, Martinez FD, Guerra S. "Reply to Bush: Low Lung Function in Young Adult Life Is Associated with Early Mortality." Am. J. Respir. Crit. Care Med.. 2018;197(4):539. PMCID: PMC5821910  PMID: 28925717

F Dijk N, Xu C, Melén E, et al. "Genetic regulation of methylation and IL1RL1-a protein levels in asthma." Eur. Respir. J.. 2018;51(3).

Xu C-J, Söderhäll C, Bustamante M, et al. "DNA methylation in childhood asthma: an epigenome-wide meta-analysis." Lancet Respir Med. 2018;6(5):379-388.

Vasquez MM, Sherrill DL, LeVan TD, Morgan WJ, Sisson JH, Guerra S. "Persistent light to moderate alcohol intake and lung function: A longitudinal study." Alcohol. 2018;67:65-71. PMCID: PMC5826814  PMID: 29396309

Zhai J, Stern DA, Sherrill DL, et al. "Trajectories and Early Determinants of Circulating CC16 from Birth to Age 32 Years." Am. J. Respir. Crit. Care Med.. 2018;198(2):267-270. PMCID: PMC6058982  PMID: 29485918

Hiranrattana A, Stern DA, Guerra S, et al. "sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics." Thorax. 2018;73(12):1170-1173.


Diaz AA, Rahaghi FN, Doyle TJ, et al. "Differences in Respiratory Symptoms and Lung Structure Between Hispanic and Non-Hispanic White Smokers: A Comparative Study." Chronic Obstr Pulm Dis. 2017;4(4):297-304. PMCID: PMC5764843  PMID: 29354674

Melén E, Guerra S. "Recent advances in understanding lung function development." F1000Res. 2017;6:726. PMCID: PMC5461903 

Chen Y, Vasquez MM, Zhu L, et al. "Effects of Retinoids on Augmentation of Club Cell Secretory Protein." Am. J. Respir. Crit. Care Med.. 2017;196(7):928-931. PMCID: PMC5649971  PMID: 28231434

Chang EH, Willis AL, McCrary HC, et al. "Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis." J. Allergy Clin. Immunol.. 2017;139(6):1990-1992.e2. PMCID: PMC5457723  PMID: 27923563

Vasquez MM, McClure LA, Sherrill DL, et al. "Positive Airway Pressure Therapies and Hospitalization in Chronic Obstructive Pulmonary Disease." Am. J. Med.. 2017;130(7):809-818. PMCID: PMC5474150  PMID: 28089799

Aguilar D, Pinart M, Koppelman GH, et al. "Computational analysis of multimorbidity between asthma, eczema and rhinitis." PLoS ONE. 2017;12(6):e0179125. PMCID: PMC5466323 


Clinical Trials

Study Title (link to more info on this site) Link to Studysort descending Trial Status Principal Investigator
Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD) Current Trial - Enrollment Complete Stefano Guerra , MD, PhD, MPH, Fernando Martinez, MD
Tucson Children's Respiratory Study (TCRS) Current Trial - Enrollment Complete Stefano Guerra , MD, PhD, MPH, Fernando Martinez, MD
CC16 COVID Pilot Current Trial - Enrolling Stefano Guerra , MD, PhD, MPH