Steroids in Eosinophil Negative Asthma (SIENA)

Trial Status: 


Most people with asthma have inflammation in their airway. Asthma controller medications, like inhaled corticosteroids, are meant to reduce inflammation in the airway. Reducing airway inflammation should make one’s breathing easier. However, many people with asthma don’t breathe easier when they take an inhaled corticosteroid. We know that there are several types of cells that can cause airway inflammation, and that inhaled corticosteroids mostly target only one cell called the eosinophil. This study looks at two different inhalers, one inhaled steroid and one long-acting bronchodilator, to find out if people should take an asthma controller medication based on the type of inflammatory cells present in their airway. 


Children at least 12 years of age and adults of all ages may be eligible to join the study.

For more information, visit the AsthmaNet web site.


The National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)


AsthmaNet Network


Principal Investigator:

Fernando Martinez, MD

Contact Information:

Office: (520) 626-9543


Principal Investigator: 
Research Area: 
Clinical and Population Research