Fernando Martinez, MD

Regents' Professor
Director, A2DRC
Swift-McNear Professor of Pediatrics
Chalfont/Moore Chair on Respiratory Medicine
Professor, BIO5 Institute
Professor, Genetics - GIDP
Professor, Pediatrics

Research Interest:

Asthma and gene-environment interactions.

Selected Publications

2022

Voraphani N, Stern DA, Zhai J, et al. "The role of growth and nutrition in the early origins of spirometric restriction in adult life: a longitudinal, multicohort, population-based study." Lancet Respir Med. 2022;10(1):59-71. PMID: 34843665

2021

Phipatanakul W, Mauger DT, Guilbert TW, et al. "Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation." Contemp Clin Trials. 2021;100:106228. PMCID: PMC7887056  PMID: 33242697

Hallmark B, Wegienka G, Havstad S, et al. "Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood." Am J Respir Crit Care Med. 2021;203(7):864-870. PMCID: PMC8017591  PMID: 33535024

Pivniouk V, Gimenes-Junior JA, Ezeh P, et al. "Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis." J Allergy Clin Immunol. 2021. PMID: 34560105

Ortega VE, Daya M, Szefler SJ, et al. "Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma." Lancet Child Adolesc Health. 2021;5(12):862-872. PMCID: PMC8787857  PMID: 34762840

Johnson CC, Havstad SL, Ownby DR, et al. "Pediatric asthma incidence rates in the United States from 1980 to 2017." J Allergy Clin Immunol. 2021;148(5):1270-1280. PMCID: PMC8631308  PMID: 33964299

Ryan PH, Brokamp C, Blossom J, et al. "A distributed geospatial approach to describe community characteristics for multisite studies." J Clin Transl Sci. 2021;5(1):e86. PMCID: PMC8111696  PMID: 34007469

Johnson MDL, Younis US, Menghani SV, et al. "CC16 Binding to αβ Integrin Protects against Infection." Am J Respir Crit Care Med. 2021;203(11):1410-1418. PMCID: PMC8456541  PMID: 33326355

2020

Chang EH, Willis AL, Romanoski CE, et al. "Rhinovirus Infections in Individuals with Asthma Increase ACE2 Expression and Cytokine Pathways Implicated in COVID-19." Am J Respir Crit Care Med. 2020;202(5):753-755. PMCID: PMC7462393  PMID: 32649217

Kimura H, Francisco D, Conway M, et al. "Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells." J Allergy Clin Immunol. 2020;146(1):80-88.e8. PMCID: PMC7227558  PMID: 32422146

Polverino F, Stern DA, Ruocco G, et al. "Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)." Front Cardiovasc Med. 2020;7:585866. PMCID: PMC7583635 

Guerra S, Lombardi E, Stern DA, et al. "Fetal Origins of Asthma: A Longitudinal Study from Birth to Age 36 Years." Am. J. Respir. Crit. Care Med.. 2020. PMID: 32649838

2019

Beamer PI, Furlong M, Lothrop N, et al. "CC16 Levels into Adult Life are Associated with Nitrogen Dioxide Exposure at Birth." Am. J. Respir. Crit. Care Med.. 2019. PMID: 30789752

Gerald JK, Hallmark B, Billheimer D, Martinez FD, Gerald LB. "Are Latino children of Mexican origin with asthma less responsive to inhaled corticosteroids than white children?" J Allergy Clin Immunol Pract. 2019.

Zhai J, Insel M, Addison KJ, et al. "Club Cell Secretory Protein Deficiency Leads to Altered Lung Function." Am. J. Respir. Crit. Care Med.. 2019;199(3):302-312. PMCID: PMC6363971  PMID: 30543455

Martinez FD. "Childhood Asthma Inception and Progression: Role of Microbial Exposures, Susceptibility to Viruses and Early Allergic Sensitization." Immunol Allergy Clin North Am. 2019;39(2):141-150. PMCID: PMC6613822  PMID: 30954166

2018

Kothari PH, Qiu W, Croteau-Chonka DC, et al. "Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus." J. Allergy Clin. Immunol.. 2018;141(6):2282-2286.e6. PMCID: PMC5994185  PMID: 29374573

Carr TF, Stern DA, Halonen M, Wright AL, Martinez FD. "Non-atopic rhinitis at age 6 is associated with subsequent development of asthma." Clin. Exp. Allergy. 2018. PMID: 30220097

Fitzpatrick AM, Bacharier LB, Guilbert TW, et al. "Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation." J Allergy Clin Immunol Pract. 2018.

Martinez FD, Guerra S. "Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction." Am. J. Respir. Crit. Care Med.. 2018;197(5):573-579. PMCID: PMC6005239  PMID: 29048927

Lang JE, Fitzpatrick AM, Mauger DT, et al. "Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids." J. Allergy Clin. Immunol.. 2018;141(4):1459-1467.e2. PMID: 29273557

Hiranrattana A, Stern DA, Guerra S, et al. "sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics." Thorax. 2018;73(12):1170-1173.

Chang EH, Stern DA, Willis AL, Guerra S, Wright AL, Martinez FD. "Early life risk factors for chronic sinusitis: A longitudinal birth cohort study." J. Allergy Clin. Immunol.. 2018;141(4):1291-1297.e2. PMCID: PMC5937937  PMID: 29355680

Vasquez MM, Zhou M, Hu C, Martinez FD, Guerra S. "Reply to Bush: Low Lung Function in Young Adult Life Is Associated with Early Mortality." Am. J. Respir. Crit. Care Med.. 2018;197(4):539. PMCID: PMC5821910  PMID: 28925717

Zhai J, Stern DA, Sherrill DL, et al. "Trajectories and Early Determinants of Circulating CC16 from Birth to Age 32 Years." Am. J. Respir. Crit. Care Med.. 2018;198(2):267-270. PMCID: PMC6058982  PMID: 29485918

Pages

Clinical Trials

Study Title (link to more info on this site)sort descending Link to Study Trial Status Principal Investigator
(ORBEX) Randomized, placebo-controlled, multicenter study to assess the efficacy, safety, and tolerability of Oral Bacterial Extract for the prevention of wheezing lower respiratory tract illness Current Trial - Enrolling Fernando Martinez, MD, Wayne J. Morgan, MD
BEAMS Current Trial - Enrolling Paloma Beamer, PhD, Dean Billheimer, PhD, Tara F. Carr, MD, Darren A. Cusanovich, PhD, Fernando Martinez, MD, Donata Vercelli, MD, Anne L. Wright, PhD
Best African American Response to Asthma Drugs (BARD) Closed Fernando Martinez, MD
Best African American Response to Asthma Drugs (BARD) Closed Fernando Martinez, MD
Infant Immune Study (IIS) Current Trial - Enrollment Complete Marilyn Halonen, PhD, Fernando Martinez, MD, Wayne J. Morgan, MD, Anne L. Wright, PhD
Pathways to Immunologically Mediated Asthma (PIMA) Current Trial - Enrollment Complete Fernando Martinez, MD
Preventing Asthma in High Risk Kids (PARK) Current Trial - Enrolling Fernando Martinez, MD
Step-Up Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations (STICS) Closed Fernando Martinez, MD
Steroids in Eosinophil Negative Asthma (SIENA) Current Trial - Enrollment Complete Fernando Martinez, MD
Steroids in Eosinophil Negative Asthma (SIENA) Closed Fernando Martinez, MD
TReating Children to Prevent EXacerbations of Asthma (TREXA) Current Trial - Enrollment Complete Fernando Martinez, MD, Wayne J. Morgan, MD
Tucson Children's Respiratory Study (TCRS) Current Trial - Enrollment Complete Stefano Guerra , MD, PhD, MPH, Fernando Martinez, MD
Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD) Current Trial - Enrollment Complete Stefano Guerra , MD, PhD, MPH, Fernando Martinez, MD