Fernando Martinez, MD

Regents' Professor
Director, Asthma & Airway Disease Research Center
Swift-McNear Professor of Pediatrics

Research Interest:

Asthma and gene-environment interactions.

Selected Publications

2023

Guerra S, Ledford JG, Melén E, et al. "Creatine Kinase Is Decreased in Childhood Asthma." Am J Respir Crit Care Med. 2023;207(5):544-552. PMCID: PMC10870915  PMID: 35876143

Carr TF, Stern DA, Morgan W, Guerra S, Martinez FD. "Elevated Childhood Insulin-related Asthma Is a Risk Factor for Reduced Lung Function." Am J Respir Crit Care Med. 2023;207(6):790-792. PMCID: PMC10037476  PMID: 36521027

2022

Voraphani N, Stern DA, Zhai J, et al. "The role of growth and nutrition in the early origins of spirometric restriction in adult life: a longitudinal, multicohort, population-based study." Lancet Respir Med. 2022;10(1):59-71. PMID: 34843665

2021

Ortega VE, Daya M, Szefler SJ, et al. "Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma." Lancet Child Adolesc Health. 2021;5(12):862-872. PMCID: PMC8787857  PMID: 34762840

Johnson CC, Havstad SL, Ownby DR, et al. "Pediatric asthma incidence rates in the United States from 1980 to 2017." J Allergy Clin Immunol. 2021;148(5):1270-1280. PMCID: PMC8631308  PMID: 33964299

Phipatanakul W, Mauger DT, Guilbert TW, et al. "Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation." Contemp Clin Trials. 2021;100:106228. PMCID: PMC7887056  PMID: 33242697

Ryan PH, Brokamp C, Blossom J, et al. "A distributed geospatial approach to describe community characteristics for multisite studies." J Clin Transl Sci. 2021;5(1):e86. PMCID: PMC8111696  PMID: 34007469

Johnson MDL, Younis US, Menghani SV, et al. "CC16 Binding to αβ Integrin Protects against Infection." Am J Respir Crit Care Med. 2021;203(11):1410-1418. PMCID: PMC8456541  PMID: 33326355

Hallmark B, Wegienka G, Havstad S, et al. "Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood." Am J Respir Crit Care Med. 2021;203(7):864-870. PMCID: PMC8017591  PMID: 33535024

Pivniouk V, Gimenes-Junior JA, Ezeh P, et al. "Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis." J Allergy Clin Immunol. 2021. PMID: 34560105

2020

Kimura H, Francisco D, Conway M, et al. "Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells." J Allergy Clin Immunol. 2020;146(1):80-88.e8. PMCID: PMC7227558  PMID: 32422146

Guerra S, Lombardi E, Stern DA, et al. "Fetal Origins of Asthma: A Longitudinal Study from Birth to Age 36 Years." Am. J. Respir. Crit. Care Med.. 2020. PMID: 32649838

Chang EH, Willis AL, Romanoski CE, et al. "Rhinovirus Infections in Individuals with Asthma Increase ACE2 Expression and Cytokine Pathways Implicated in COVID-19." Am J Respir Crit Care Med. 2020;202(5):753-755. PMCID: PMC7462393  PMID: 32649217

Polverino F, Stern DA, Ruocco G, et al. "Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)." Front Cardiovasc Med. 2020;7:585866. PMCID: PMC7583635 

2019

Beamer PI, Furlong M, Lothrop N, et al. "CC16 Levels into Adult Life are Associated with Nitrogen Dioxide Exposure at Birth." Am. J. Respir. Crit. Care Med.. 2019. PMID: 30789752

Zhai J, Insel M, Addison KJ, et al. "Club Cell Secretory Protein Deficiency Leads to Altered Lung Function." Am. J. Respir. Crit. Care Med.. 2019;199(3):302-312. PMCID: PMC6363971  PMID: 30543455

Gerald JK, Hallmark B, Billheimer D, Martinez FD, Gerald LB. "Are Latino children of Mexican origin with asthma less responsive to inhaled corticosteroids than white children?" J Allergy Clin Immunol Pract. 2019.

Martinez FD. "Childhood Asthma Inception and Progression: Role of Microbial Exposures, Susceptibility to Viruses and Early Allergic Sensitization." Immunol Allergy Clin North Am. 2019;39(2):141-150. PMCID: PMC6613822  PMID: 30954166

2018

Hiranrattana A, Stern DA, Guerra S, et al. "sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics." Thorax. 2018;73(12):1170-1173.

Carr TF, Stern DA, Halonen M, Wright AL, Martinez FD. "Non-atopic rhinitis at age 6 is associated with subsequent development of asthma." Clin. Exp. Allergy. 2018. PMID: 30220097

Martinez FD, Guerra S. "Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction." Am. J. Respir. Crit. Care Med.. 2018;197(5):573-579. PMCID: PMC6005239  PMID: 29048927

Wedzicha JA, Martinez FD. "Asthma: Upcoming Themed Issue." Am. J. Respir. Crit. Care Med.. 2018;198(5):549.

Lang JE, Fitzpatrick AM, Mauger DT, et al. "Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids." J. Allergy Clin. Immunol.. 2018;141(4):1459-1467.e2. PMID: 29273557

Chang EH, Stern DA, Willis AL, Guerra S, Wright AL, Martinez FD. "Early life risk factors for chronic sinusitis: A longitudinal birth cohort study." J. Allergy Clin. Immunol.. 2018;141(4):1291-1297.e2. PMCID: PMC5937937  PMID: 29355680

Vasquez MM, Zhou M, Hu C, Martinez FD, Guerra S. "Reply to Bush: Low Lung Function in Young Adult Life Is Associated with Early Mortality." Am. J. Respir. Crit. Care Med.. 2018;197(4):539. PMCID: PMC5821910  PMID: 28925717

Pages

Clinical Trials

Study Title (link to more info on this site)sort descending Link to Study Trial Status Principal Investigator
(ORBEX) Randomized, placebo-controlled, multicenter study to assess the efficacy, safety, and tolerability of Oral Bacterial Extract for the prevention of wheezing lower respiratory tract illness https://breatheeasyearly.info/?com=1 Closed Fernando Martinez, MD, Wayne J. Morgan, MD
BEAMS view Current Trial - Enrolling Paloma Beamer, PhD, Dean Billheimer, PhD, Tara F. Carr, MD, Darren A. Cusanovich, PhD, Fernando Martinez, MD, Donata Vercelli, MD
Best African American Response to Asthma Drugs (BARD) https://lungresearch.arizona.edu/study/bard Closed Fernando Martinez, MD
Best African American Response to Asthma Drugs (BARD) https://lungresearch.arizona.edu/study/bard Closed Fernando Martinez, MD
Infant Immune Study (IIS) view Current Trial - Enrollment Complete Marilyn Halonen, PhD, Fernando Martinez, MD, Wayne J. Morgan, MD
Pathways to Immunologically Mediated Asthma (PIMA) view Current Trial - Enrollment Complete Fernando Martinez, MD
Preventing Asthma in High Risk Kids (PARK) https://studies.medicine.arizona.edu/trials/preventing-asthma-high-risk-kids-par… Closed Fernando Martinez, MD
Step-Up Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations (STICS) https://lungresearch.arizona.edu/study/stics Closed Fernando Martinez, MD
Steroids in Eosinophil Negative Asthma (SIENA) https://lungresearch.arizona.edu/study/siena Closed Fernando Martinez, MD
Steroids in Eosinophil Negative Asthma (SIENA) view Current Trial - Enrollment Complete Fernando Martinez, MD
TReating Children to Prevent EXacerbations of Asthma (TREXA) https://clinicaltrials.gov/ct2/show/NCT00394329?term=CARE%20Network&cond=Asthma&… Current Trial - Enrollment Complete Fernando Martinez, MD, Wayne J. Morgan, MD
Tucson Children's Respiratory Study (TCRS) view Current Trial - Enrollment Complete Stefano Guerra , MD, PhD, MPH, Fernando Martinez, MD
Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD) view Current Trial - Enrollment Complete Stefano Guerra , MD, PhD, MPH, Fernando Martinez, MD