Fernando Martinez, MD

Regents' Professor
Director, A2DRC
Swift-McNear Professor of Pediatrics
Chalfont/Moore Chair on Respiratory Medicine
Professor, BIO5 Institute
Professor, Genetics - GIDP
Professor, Pediatrics

Research Interest:

Asthma and gene-environment interactions.

Selected Publications

2019

Gerald JK, Hallmark B, Billheimer D, Martinez FD, Gerald LB. "Are Latino children of Mexican origin with asthma less responsive to inhaled corticosteroids than white children?" J Allergy Clin Immunol Pract. 2019.

Martinez FD. "Childhood Asthma Inception and Progression: Role of Microbial Exposures, Susceptibility to Viruses and Early Allergic Sensitization." Immunol Allergy Clin North Am. 2019;39(2):141-150. PMCID: PMC6613822  PMID: 30954166

Beamer PI, Furlong M, Lothrop N, et al. "CC16 Levels into Adult Life are Associated with Nitrogen Dioxide Exposure at Birth." Am. J. Respir. Crit. Care Med.. 2019. PMID: 30789752

Zhai J, Insel M, Addison KJ, et al. "Club Cell Secretory Protein Deficiency Leads to Altered Lung Function." Am. J. Respir. Crit. Care Med.. 2019;199(3):302-312. PMCID: PMC6363971  PMID: 30543455

2018

Chang EH, Stern DA, Willis AL, Guerra S, Wright AL, Martinez FD. "Early life risk factors for chronic sinusitis: A longitudinal birth cohort study." J. Allergy Clin. Immunol.. 2018;141(4):1291-1297.e2. PMCID: PMC5937937  PMID: 29355680

Vasquez MM, Zhou M, Hu C, Martinez FD, Guerra S. "Reply to Bush: Low Lung Function in Young Adult Life Is Associated with Early Mortality." Am. J. Respir. Crit. Care Med.. 2018;197(4):539. PMCID: PMC5821910  PMID: 28925717

Zhai J, Stern DA, Sherrill DL, et al. "Trajectories and Early Determinants of Circulating CC16 from Birth to Age 32 Years." Am. J. Respir. Crit. Care Med.. 2018;198(2):267-270. PMCID: PMC6058982  PMID: 29485918

Fitzpatrick AM, Bacharier LB, Guilbert TW, et al. "Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation." J Allergy Clin Immunol Pract. 2018.

Kothari PH, Qiu W, Croteau-Chonka DC, et al. "Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus." J. Allergy Clin. Immunol.. 2018;141(6):2282-2286.e6. PMCID: PMC5994185  PMID: 29374573

Hiranrattana A, Stern DA, Guerra S, et al. "sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics." Thorax. 2018;73(12):1170-1173.

Carr TF, Stern DA, Halonen M, Wright AL, Martinez FD. "Non-atopic rhinitis at age 6 is associated with subsequent development of asthma." Clin. Exp. Allergy. 2018. PMID: 30220097

Martinez FD, Guerra S. "Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction." Am. J. Respir. Crit. Care Med.. 2018;197(5):573-579. PMCID: PMC6005239  PMID: 29048927

Wedzicha JA, Martinez FD. "Asthma: Upcoming Themed Issue." Am. J. Respir. Crit. Care Med.. 2018;198(5):549.

Lang JE, Fitzpatrick AM, Mauger DT, et al. "Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids." J. Allergy Clin. Immunol.. 2018;141(4):1459-1467.e2. PMID: 29273557

2017

Gardeux V, Berghout J, Achour I, et al. "A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations." J Am Med Inform Assoc. 2017;24(6):1116-1126. PMCID: PMC6080688  PMID: 29016970

Chen Y, Vasquez MM, Zhu L, et al. "Effects of Retinoids on Augmentation of Club Cell Secretory Protein." Am. J. Respir. Crit. Care Med.. 2017;196(7):928-931. PMCID: PMC5649971  PMID: 28231434

Chang EH, Willis AL, McCrary HC, et al. "Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis." J. Allergy Clin. Immunol.. 2017;139(6):1990-1992.e2. PMCID: PMC5457723  PMID: 27923563

Woodruff PG, van den Berge M, Boucher RC, et al. "American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report." Am. J. Respir. Crit. Care Med.. 2017;196(3):375-381. PMCID: PMC5549872  PMID: 28636425

Vasquez MM, Zhou M, Hu C, Martinez FD, Guerra S. "Low Lung Function in Young Adult Life Is Associated with Early Mortality." Am. J. Respir. Crit. Care Med.. 2017;195(10):1399-1401. PMCID: PMC5443902  PMID: 28504596

Carr TF, Beamer PI, Rothers J, et al. "Prevalence of Asthma in School Children on the Arizona-Sonora Border." J Allergy Clin Immunol Pract. 2017;5(1):114-120.e2. PMCID: PMC5222738  PMID: 27544711

Oren E, Gerald L, Stern DA, Martinez FD, Wright AL. "Self-Reported Stressful Life Events During Adolescence and Subsequent Asthma: A Longitudinal Study." J Allergy Clin Immunol Pract. 2017;5(2):427-434.e2. PMCID: PMC5591640  PMID: 27815066

Martinez FD. "Bending the Twig Does the Tree Incline: Lung Function after Lower Respiratory Tract Illness in Infancy." Am. J. Respir. Crit. Care Med.. 2017;195(2):154-155. PMCID: PMC5394793  PMID: 28084817

Clinical Trials

Study Title (link to more info on this site)sort ascending Link to Study Trial Status Principal Investigator
Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD) Current Trial - Enrollment Complete Stefano Guerra , MD, PhD, MPH, Fernando Martinez, MD
Tucson Children's Respiratory Study (CRS) Current Trial - Enrollment Complete Eugene Chang, MD, Stefano Guerra , MD, PhD, MPH, Marilyn Halonen, PhD, Fernando Martinez, MD, Wayne J. Morgan, MD, Anne L. Wright, PhD
TReating Children to Prevent EXacerbations of Asthma (TREXA) Current Trial - Enrollment Complete Fernando Martinez, MD, Wayne J. Morgan, MD
Steroids in Eosinophil Negative Asthma (SIENA) Closed Fernando Martinez, MD
Steroids in Eosinophil Negative Asthma (SIENA) Current Trial - Enrollment Complete Fernando Martinez, MD
Step-Up Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations (STICS) Closed Fernando Martinez, MD
Preventing Asthma in High Risk Kids (PARK) Current Trial - Enrolling Fernando Martinez, MD
Pathways to Immunologically Mediated Asthma (PIMA) Current Trial - Enrollment Complete Fernando Martinez, MD
Infant Immune Study (IIS) Current Trial - Enrollment Complete Stefano Guerra , MD, PhD, MPH, Marilyn Halonen, PhD, Fernando Martinez, MD, Wayne J. Morgan, MD, Anne L. Wright, PhD
Best African American Response to Asthma Drugs (BARD) Closed Fernando Martinez, MD
Best African American Response to Asthma Drugs (BARD) Closed Fernando Martinez, MD